Besides his role as agent Lee Hobson on "The Untouchables" from 1960 to 1963, Picerni starred in "House of Wax" with Vincent Price in 1953. It was the first 3-D movie produced by a major studio. His other films included "The Scalphunters" in 1968 and "Airport" in 1970.
Picerni's appeared in TV shows including "Gunsmoke," "Kojak," "T.J. Hooker" and "Perry Mason."