HOUSTON --A Houston woman is accused of killing her estranged husband by running over him with her car several times. April Holmes is being held at the Harris County Jail on a $50,000 bond. Eyewitnesses who were interviewed a short time after the incident said this was no accident. Holmes went before a judge Tuesday afternoon to hear the charge against her. The 29-year-old is accused of killing her estranged husband by intentionally running him down with her car then rolling over him at least four times. "The witnesses also reported that he was screaming and crying for help. He then threw his cell phone out to one of the witnesses to call the police," said Donna Hawkins of the Harris Co. District Attorney's Office. Donald Holmes became pinned underneath the white Pontiac Bonneville after his wife allegedly struck him while he was walking, backed over him, then drove forward hitting him again. It happened Monday night in the middle of a residential neighborhood at Balarama and Beckford in southwest Houston. A friend who rushed to the scene says she overheard April Holmes say it was an accident, but the friend said she didn't believer her. "I seen how he was. That couldn't have been an accident," said Denitrice Henley. Investigators say they found the car in the middle of the street with Holmes still behind the wheel. She was immediately taken into custody. When asked in court if she would be hiring an attorney, April Holmes replied, "I haven't decided yet." Donald Holmes, 29, died on the way to the hospital as a result of his injuries. Investigators say the couple had been separated for quite some time because they were having marital problems. If convicted, April Holmes could face anywhere from five to 99 years in prison and up to a $10,000 fine.