Southern Miss (15-9, 5-5 Conference USA) led by three at the break and 38-34 just over 6 minutes into the second half, but went on a game-deciding run from that juncture. The Golden Eagles hit six straight free throws followed by a 3-pointer from Maurice Bolden during a 16-6 run, taking a 54-40 lead they wouldn't relinquish.
Lawrence Ghoram paced the Owls (8-16, 1-9) with 13 points and Lucas Kuipers added 12.
The Golden Eagles have won five of their last six games, while the Owls have lost three of four.