The previous mark of 51 was set by Kentucky between 1950 and 1954.
Williams finished with 32 points a week after he scored 33 against Southern Mississippi. He made 9 of 15 from the floor, including three 3-pointers.
Arsalan Kazemi picked up his fourth double-double of the season for the Owls (6-11, 0-4), scoring 15 points and pulling down 11 rebounds. Trey Stanton led the Owls with 18 points.
Roburt Sallie helped the Tigers with 12 points, while Willie Kemp finished with 11.