Officials say the deceased are two men, ages 52 and 32, and two women, ages 43 and 60.
A 71-year-old resident is being treated at a Utica hospital, and the other four residents were relocated to another home. The two staff members also survived.
The fire started around 5:30 a.m. Saturday at the ranch-style residence in Wells, located 56 miles northwest of Albany.
State police and fire investigators are working to determine the cause of the fire.
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